Know Your Definitions
Cannabis Sativa L. - Source of medical cannabis and agricultural hemp, contains over 120 cannabinoids.
Medical Cannabis - Cannabis for medical purposes, Marijuana (MJ), cannabis for recreational purposes.
Agricultural or Industrial Hemp - less than 0.3% THC by dry weight, use of whole plant.

History Of Cannabis
• First reported as medicine around 8,000 years ago.
• Introduced into Western medicine in 1840s by Dr. W.B. O’Shaughnessy.
• Available in 1906 Mfg. by Eli Lilly, Wyeth Park-Davis, Sharp and Dohme.
• Cannabis extract from cannabis plants was the medicine of choice in the early 1930s.
• Promoted as analgesic, sedative, antiinflammatory, antispasmotic, and anticonvulsant properties.

The Endocannabinoid System (ECS)
• ECS - Endocannabinoids, the enzymes that regulate their production and degradation, and their receptors.
• Endocannabinoids are “messengers”, isolated from brain and peripheral tissues that communicate via Cannabinoid Receptors: Anandamide and 2AG. Main Receptors: CB1 and CB2
• Involved in the direct regulation of appetite, metabolic health, pain/inflammation, thermoregulation, intra-ocular pressure, sensation, muscle control, motivation/reward, mood, and memory.
• Involved in learning and synaptic plasticity.

...modulating ECS activity may have therapeutic potential in almost all diseases affecting humans, including obesity/metabolic syndrome, diabetes and diabetic complications, neurodegenerative, inflammatory, cardiovascular, liver, gastrointestinal, skin diseases, pain, psychiatric disorders, cachexia, cancer, chemotherapy-induced nausea and vomiting, among many others. - National Institute of Health, May 2014

Comparing Hemp To Medical Cannabis
Outdoor Grown Agricultural Hemp - Sequesters CO2 • Environmentally Helpful • Requires 80% less water • Sun Powered Outdoor Grown • No artificial light Sources required • Textbook Sustainability.
Indoor Grown Medical Cannabis - Enormous Carbon Foot Print • Environmentally Harmful • Wasteful Water Demands • Huge Strain on Power Grid • Unsustainable.

Does Source of CBD Matter? NO!
• CBD is CBD!
• CBD from Agricultural Hemp or high-CBD strain Medical Cannabis act the same in our bodies.
• CBD from Agricultural Hemp affords a non-psychotoxic option.

The Hemptourage Effect: Whole Plant Synergy
Entourage Effect - Refers to the idea that different constituents of cannabis work synergistically • Overstates the importance of THC • Ignores the benefits from all the other parts of the plant not used when only ingesting flowers.
Hemptourage Effect - refers to the idea that you get superior synergistic benefit from ingesting the over 500 components found in the whole plant • Minimal THC.

The Difference Between Oils
Raw (Brown Label) - The raw oil is a total plant CO2 extract from agricultural hemp, imported from Europe. Cannabidiolic Acid, or CBDA, comprises a significant proportion of the extracted cannabinoids in the raw oil. CBDA is an acidic cannabinoid, the naturally-occurring raw form of CBD that is produced directly in the plant, and contains many beneficial properties distinct from CBD.
Decarboxylation Distilled: Total Plant Complex (Green Label) - The raw oil undergoes a process called decarboxylation (a gentle heating process), in which most of the remaining CBDA is converted into CBD to maximize the concentration of CBD. For example, if the raw oil consisted of 100 milligrams of CBDA and 100 milligrams of CBD, the decarb oil will contain a sum of 200 milligrams of CBD after decarboxylation, along with many of the cannabinoids, terpenes, plant sterols, vitamin E and other natural plant material that comprises our Total Plant Complex.
Distilled: Gold Formula (Gold Label) - Our Gold Formula is the ultimate step in refining our oil, where excess plant material is distilled from our decarboxylated oil in a solvent-free process, rendering the oil gold in color. The final oil comprises only of CBD, minor cannabinoids, and plant-derived fatty acids. Our Gold Formula oil is the highest-concentrated form of CBD oil that we offer.

Why Don’t We Have More Research?
Cannabis is listed as a Schedule 1 drug, making it difficult to conduct research over certain limits.
• CBD is not directly scheduled, there is no reference of CBD in the Federal Acts.

Agricultural Hemp is not a controlled substance.
• Only allowed to be grown under research oversight and illegal to commercially grow and extract in US.

Good source material for phytocannabinoids is difficult to obtain.
• Issues with growing, selling, and transporting across state lines.
• Can be imported.

CBD’s Remarkable Safety Profile
Studies showing CBD as non-toxic. Does not induce changes on food intake, does not induce catalepsy, does not affect physiological parameters (heart rate, blood pressure and body temperature). Does not affect gastrointestinal transit nor alter psychomotor or psychological functions. Chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans. Conclusion: Based on recent advances in cannabinoid administration in humans, CBD shows safety in humans and animals.

State of Legal Issues
• Hemp is not defined as “marijuana” under the Controlled Substances Act (CSA). Expressly and intentionally excludes: mature stalks, fiber from stalks, oil or cake made from seeds, any other compound, manufacture, salt, derivative, mixture, or preparation of such mature stalks (except resin extracted therefrom), fiber, oil, or cake, or the sterilized seed of such plant which is incapable of germination.
• Naturally occurring cannabinoids in agricultural hemp foods, including oils, were never scheduled under the CSA.
• Agricultural hemp fiber, stalk, seed, and oils can be lawfully imported into the United States and these portions of the hemp plant may enter into US commerce.
• CV Sciences uses EU-certified, Fiber-type, low-THCA cultivars of hemp to grow in accordance to Federal Guidelines.

What to Look For In a CBD Company and Product?
• Full Traceability
• No medical claims or dosing recommendations
• Efforts to grow research
• GRAS self-determination/safety assessments
• Commitment to Education
• Involvement with Trade Organizations